What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease (n=146). Intervention: Atrioventricular plane displacement (AVPD) assessment vs. Healthy subjects. Primary outcome: Correlation between mean atrioventricular plane displacement and left ventricular ejection fraction (r = 0.89, p=<0.001).

What question did this study set out to answer?

The aim is to evaluate the significance of atrioventricular plane displacement as a measure of left ventricular function in patients with coronary artery disease.

February 1, 1992European Heart Journal

Haemodynamic significance of the atrioventricular plane displacement in patients with coronary artery disease

Q: What are the key findings of this study?

Echocardiographic assessment of mean atrioventricular plane displacement strongly correlated with angiographic LVEF (r=0.89, P<0.001), with an AVmean ≥10 mm yielding 92% sensitivity and 87% specificity.

Q: What question did this study set out to answer?

The aim is to evaluate the significance of atrioventricular plane displacement as a measure of left ventricular function in patients with coronary artery disease.

View Full Paper

Ask AI

Bookmark

Key result

Echocardiographic assessment of mean atrioventricular plane displacement strongly correlated with angiographic LVEF (r=0.89, P<0.001), with an AVmean ≥10 mm yielding 92% sensitivity and 87% specificity.

Why the study?

Does echocardiographic assessment of atrioventricular plane displacement accurately estimate global left ventricular function in patients with coronary artery disease?

Population

106 patients with coronary artery disease with or without previous myocardial infarction and 40 age-matched…

Comparison

Echocardiographic quantitative assessment of the… vs Age-matched healthy subjects and…

Design

Cross-sectional

Authors

MAMohammad Afaque AlamTulane University CHChrister HöglundRoche (Switzerland)CTCurt ThorstrandKarolinska Institutet

Discussion

Member takes

Implication

May support AV plane displacement as an LVEF surrogate in CAD; hypothesis-generating and requires prospective validation before adoption.

Key Points

The aim is to evaluate the significance of atrioventricular plane displacement as a measure of left ventricular function in patients with coronary artery disease.
Echocardiographic assessment of atrioventricular plane displacement in 106 patients with CAD and 40 healthy subjects.
Measurement of AVPD from apical views at four left ventricular sites.
Correlation analysis between AVmean and left ventricular ejection fraction derived from cineangiograms.
AVmean was significantly lower in patients with CAD compared to healthy subjects (P<0.001).
A strong correlation between AVmean and LVEF was noted (r=0.89, P<0.001).
Using an AVmean cut-off of 10 mm, sensitivity was 92% and specificity was 87% for predicting normal left ventricular systolic function.

Study Design

Type

Observational (n=146)

Structured PICO

Does echocardiographic assessment of atrioventricular plane displacement accurately estimate global left ventricular function in patients with coronary artery disease?

Population

146 participants, including 106 patients with coronary artery disease and 40 age-matched healthy subjects, evaluated for left ventricular function.

Exposure

Echocardiographic quantitative assessment of the atrioventricular plane displacement (AVPD) from apical four- and two-chamber views to calculate mean displacement (AVmean)

Comparator

Age-matched healthy subjects (for AVmean comparison) and cineangiogram-derived left ventricular ejection fraction (for correlation)

Outcome

Mean atrioventricular plane displacement (AVmean) and its correlation with left ventricular ejection fraction (LVEF) calculated from cineangiogramssurrogate

Main Result

Effect estimate: r = 0.89

p-value: p=<0.001

Echocardiographic measurement of atrioventricular plane displacement provides a simple, noninvasive, and accurate method to estimate global left ventricular systolic function in patients with coronary artery disease.

Cite This Study

Alam et al. (1992) conducted an observational in Coronary artery disease (n=146). Atrioventricular plane displacement (AVPD) assessment vs. Healthy subjects was evaluated on Correlation between mean atrioventricular plane displacement and left ventricular ejection fraction (r = 0.89, p=<0.001). Echocardiographic assessment of mean atrioventricular plane displacement strongly correlated with angiographic LVEF (r=0.89, P<0.001), with an AVmean ≥10 mm yielding 92% sensitivity and 87% specificity.

synapsesocial.com/papers/6a211a2e38e3bbbbff02bc96 https://doi.org/10.1093/oxfordjournals.eurheartj.a060146

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

February 1, 1992European Heart Journal

Haemodynamic significance of the atrioventricular plane displacement in patients with coronary artery disease

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Does echocardiographic assessment of atrioventricular plane displacement accurately estimate global left ventricular function in patients with coronary artery disease?

Population

106 patients with coronary artery disease with or without previous myocardial infarction and 40 age-matched…

Comparison

Echocardiographic quantitative assessment of the… vs Age-matched healthy subjects and…

Design

Cross-sectional

Authors

MAMohammad Afaque AlamTulane University CHChrister HöglundRoche (Switzerland)CTCurt ThorstrandKarolinska Institutet

Discussion

Member takes

Implication

May support AV plane displacement as an LVEF surrogate in CAD; hypothesis-generating and requires prospective validation before adoption.

Key Points

The aim is to evaluate the significance of atrioventricular plane displacement as a measure of left ventricular function in patients with coronary artery disease.
Echocardiographic assessment of atrioventricular plane displacement in 106 patients with CAD and 40 healthy subjects.
Measurement of AVPD from apical views at four left ventricular sites.
Correlation analysis between AVmean and left ventricular ejection fraction derived from cineangiograms.
AVmean was significantly lower in patients with CAD compared to healthy subjects (P<0.001).
A strong correlation between AVmean and LVEF was noted (r=0.89, P<0.001).
Using an AVmean cut-off of 10 mm, sensitivity was 92% and specificity was 87% for predicting normal left ventricular systolic function.

Study Design

Type

Observational (n=146)

Structured PICO

Does echocardiographic assessment of atrioventricular plane displacement accurately estimate global left ventricular function in patients with coronary artery disease?

Population

146 participants, including 106 patients with coronary artery disease and 40 age-matched healthy subjects, evaluated for left ventricular function.

Exposure

Echocardiographic quantitative assessment of the atrioventricular plane displacement (AVPD) from apical four- and two-chamber views to calculate mean displacement (AVmean)

Comparator

Age-matched healthy subjects (for AVmean comparison) and cineangiogram-derived left ventricular ejection fraction (for correlation)

Outcome

Mean atrioventricular plane displacement (AVmean) and its correlation with left ventricular ejection fraction (LVEF) calculated from cineangiogramssurrogate

Main Result

Effect estimate: r = 0.89

p-value: p=<0.001

Cite This Study

synapsesocial.com/papers/6a211a2e38e3bbbbff02bc96 https://doi.org/10.1093/oxfordjournals.eurheartj.a060146

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark