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March 1, 2020Cancer Prevention ResearchOpen Access

The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions

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Key result

The nicotine metabolite ratio (NMR) is a validated biomarker for personalizing smoking cessation treatment, with further research needed on its application in diverse populations and e-cigarettes.

Why the study?

To summarize evidence on the nicotine metabolite ratio as a biomarker of nicotine metabolism and evaluate its clinical utility in personalizing smoking cessation treatments.

Does using the nicotine metabolite ratio (NMR) as a biomarker improve personalized smoking cessation treatment outcomes in smokers?

Design

Review

Authors

SSScott D. SiegelChristiana Care Health SystemCLCaryn LermanDartmouth CollegeAFAlex FlitterUniversity of Pennsylvania

Discussion

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Implication

NMR may aid personalized cessation pharmacotherapy in select patients; leaves open broader validation across populations and e-cigarettes.

Structured PICO

Does using the nicotine metabolite ratio (NMR) as a biomarker improve personalized smoking cessation treatment outcomes in smokers?

P
Population
Smokers
I
Intervention
Nicotine metabolite ratio (NMR) guided personalized smoking cessation treatment
O
Outcome
Smoking cessation treatment outcomes

The nicotine metabolite ratio (NMR) serves as a validated, genetically informed biomarker that can personalize and improve smoking cessation treatments.

Cite This Study

Siegel et al. (2020) conducted a review in Smoking cessation. Nicotine metabolite ratio (NMR) was evaluated. The nicotine metabolite ratio (NMR) is a validated biomarker for personalizing smoking cessation treatment, with further research needed on its application in diverse populations and e-cigarettes.

synapsesocial.com/papers/6a211b210236525c0302b396https://doi.org/10.1158/1940-6207.capr-19-0259
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-World Evidence — What Is It and What Can It Tell Us?2016 · 2,141 citations
  2. 2Genomic Medicine — An Updated Primer2010 · 441 citations
  3. 3Facilitated Extinction Training to Improve Pharmacotherapy for Smoking Cessation: A Pilot Feasibility Trial2017 · 11 citations