Why the study?
The study evaluated the effectiveness of using the nicotine metabolite ratio as an informed biomarker to optimize acupuncture for smoking cessation.
Does high-frequency acupuncture improve 12-week continuous abstinence rates compared to low-frequency acupuncture in smokers stratified by nicotine metabolite ratio?
Population
220 participants classified as slow or normal metabolizers by NMR
Comparison
High-frequency acupuncture vs low-frequency acupuncture
Design
Prospective two-arm open-label randomized controlled trial
Follow-up
12 weeks
Key result
High-frequency acupuncture significantly increased the 3-month sustained smoking abstinence rate compared to low-frequency acupuncture (17.3% vs 8.2%, OR 3.89), particularly among slow metabolizers.
Authors
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High-frequency acupuncture may boost smoking cessation success; extends RCT evidence on optimal dosing for acupuncture in nicotine dependence.
RCT (n=220)
Open-label
Stratified block randomization
Yes
Does high-frequency acupuncture improve 12-week continuous abstinence rates compared to low-frequency acupuncture in smokers stratified by nicotine metabolite ratio?
Odds Ratio: 3.89 (95% CI 1.36–8.11)
Absolute Event Rate: 17.3% vs 8.2%
High-frequency acupuncture significantly improves 3-month sustained smoking abstinence compared to low-frequency acupuncture, particularly among slow nicotine metabolizers.
Chen et al. (2024) conducted an RCT in Smoking cessation (n=220). High-frequency acupuncture vs. Low-frequency acupuncture (3 times a week) was evaluated on 12-week continuous abstinence rate assessed by urine cotinine levels (OR 3.89, 95% CI 1.36, 8.11). High-frequency acupuncture significantly increased the 3-month sustained smoking abstinence rate compared to low-frequency acupuncture (17.3% vs 8.2%, OR 3.89), particularly among slow metabolizers.
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