Key result
Adenosine exerted an anti-adrenergic effect on isolated ventricular myocytes that was most pronounced in failing human hearts and was abolished by pertussis toxin pretreatment.
Population
Isolated ventricular myocytes from failing human hearts, normal guinea-pig, and rat hearts
Comparison
Adenosine, with or without 8-Cyclopentyl… vs Absence of adenosine/pertussis toxin, or…
Design
Preclinical
Authors
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No immediate clinical role in heart failure; leaves open A1-Gi/Go targeting for future in vivo study.
Adenosine exerts a pronounced anti-adrenergic effect in failing human heart myocytes, mediated by A1 receptors coupled to Gi/Go proteins.
Brown et al. (1990) studied Failing human heart, normal guinea-pig and rat heart. Adenosine and pertussis toxin was evaluated on Anti-adrenergic effect (reduction in beta-adrenoceptor-induced increase in contraction). Adenosine exerted an anti-adrenergic effect on isolated ventricular myocytes that was most pronounced in failing human hearts and was abolished by pertussis toxin pretreatment.
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