Key result
Diabetes mellitus was a negative predictor of good coronary collateral circulation (OR 0.463; 95% CI 0.184-0.783; p=0.012), while serum irisin levels had no role in collateral development.
Why the study?
Irisin is thought to have cardiovascular protective effects in atherosclerosis, and patients with diabetes mellitus have lower irisin levels, prompting investigation into connections between irisin, diabetes mellitus, coronary collateral circulation, and SYNTAX score.
Do serum irisin levels correlate with coronary collateral circulation or CAD severity in patients with chronic total occlusion?
Observational (n=86)
Do serum irisin levels correlate with coronary collateral circulation or CAD severity in patients with chronic total occlusion?
Serum irisin levels are lower in patients with diabetes but do not correlate with coronary collateral development or CAD severity in patients with chronic total occlusion.
Answers are grounded in this paper and cite their sources.
DM impairs CCC development in CTO; cross-sectional data leave irisin's role unresolved.
Objective: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. Methods: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. Results: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development. Conclusion: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity.
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Aydın Akyüz (2021) conducted an observational in Chronic total occlusion (n=86). Diabetes mellitus vs. Without diabetes was evaluated on Good coronary collateral circulation development (OR 0.463, 95% CI 0.184-0.783, p=0.012). Diabetes mellitus was a negative predictor of good coronary collateral circulation (OR 0.463; 95% CI 0.184-0.783; p=0.012), while serum irisin levels had no role in collateral development.
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