Key result
This literature review summarized 21 articles on the relation of asymmetric and symmetric dimethylarginines to routinely used renal function parameters in pediatric kidney diseases.
Why the study?
Most data on dimethylarginines concern adult chronic kidney disease, leaving much fewer data on their role in paediatric renal diseases.
What is the relationship between ADMA/SDMA concentrations and routinely used renal function parameters in children with kidney diseases?
What is the relationship between ADMA/SDMA concentrations and routinely used renal function parameters in children with kidney diseases?
This review summarizes the available evidence on ADMA and SDMA as renal function parameters and cardiovascular risk factors in pediatric kidney diseases.
ADMA/SDMA may complement renal monitoring in pediatric kidney disease; leaves open routine adoption pending prospective validation.
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), inhibitors of nitric oxide synthase, play important roles in many processes in the body. Most data in the literature concern their importance in adult chronic kidney disease (CKD). According to them, SDMA well reflects the glomerular filtration rate (GFR), and higher ADMA concentrations are associated with hypertension and higher mortality. In addition, both substances are recognised cardiovascular risk factors in CKD. The purpose of this review was to summarise the studies on dimethylarginines in renal diseases in children, about which we have much fewer data. The review focuses specifically on dimethylarginine's relation to routinely used renal function parameters. Finally, we analysed 21 of the 55 articles published between 2003 and 2022 on dimethylarginines in kidney diseases in children (from birth to 18 years of age), obtained by searching PubMed/MEDLINE (search terms: "dimethylarginine" and "kidney").
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Jezierska et al. (2022) conducted a review in Paediatric kidney diseases. Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) was evaluated on Relation to routinely used renal function parameters. This literature review summarized 21 articles on the relation of asymmetric and symmetric dimethylarginines to routinely used renal function parameters in pediatric kidney diseases.
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