Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study
Key result
Virtual patient simulations suggest that increased left ventricular passive stiffness, more than impaired relaxation function, reduces exercise tolerance in HFpEF.
Why the study?
The relative impact of left ventricular diastolic dysfunction and impaired left atrial function on cardiovascular haemodynamics in HFpEF is largely unknown.
Population
Virtual patient simulations using the CircAdapt cardiovascular system model
Comparison
Impaired LV relaxation function vs increased LV passive stiffness vs impaired LA function
Design
Virtual patient simulation study
Authors
Discussion
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Member takes
Implication
Should not yet alter HFpEF care; hypothesis-generating for stiffness-targeted modeling in exercise studies.
Structured PICO
P
Population
Virtual patient simulations of heart failure with preserved ejection fraction using the CircAdapt cardiovascular system model.
E
Exposure
Simulated impairment of left ventricular (LV) relaxation function, increased LV passive stiffness, and impaired left atrial (LA) function
O
Outcome
Cardiovascular haemodynamics at rest and during exercisesurrogate
Virtual patient simulations demonstrate that increased LV passive stiffness limits exercise performance more than impaired relaxation in HFpEF.
Cite This Study
Loon et al. (2020) studied Heart failure with preserved ejection fraction (HFpEF). Increased LV passive stiffness vs. Impaired LV relaxation function was evaluated on Cardiac haemodynamics at rest and during exercise. Virtual patient simulations suggest that increased left ventricular passive stiffness, more than impaired relaxation function, reduces exercise tolerance in HFpEF.