Key result
History of high-intensity exercise (HR 4.7), T-wave inversions ≥V3 (HR 4.7), and greater LV mechanical dispersion (HR 1.4) strongly predicted life-threatening ventricular arrhythmia in AC patients.
Why the study?
Do clinical, ECG, and cardiac imaging parameters predict first-time life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy?
Cohort (n=117)
Do clinical, ECG, and cardiac imaging parameters predict first-time life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy?
Hazard Ratio: 4.7 (95% CI 1.2–17.5)
p-value: p=0.02
History of high-intensity exercise, T-wave inversions ≥V3, and greater LV mechanical dispersion strongly predict life-threatening ventricular arrhythmias in patients with arrhythmogenic cardiomyopathy, which may guide primary prevention ICD therapy.
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May inform primary prevention ICD decisions in AC; leaves open need for prospective validation before changing practice.
Lie et al. (2018) conducted a cohort in Arrhythmogenic Cardiomyopathy (n=117). High-intensity exercise, T-wave inversions ≥V3, and greater LV mechanical dispersion vs. Absence of these risk factors was evaluated on First-time life-threatening ventricular arrhythmia (HR 4.7, 95% CI 1.2-17.5, p=0.02). History of high-intensity exercise (HR 4.7), T-wave inversions ≥V3 (HR 4.7), and greater LV mechanical dispersion (HR 1.4) strongly predicted life-threatening ventricular arrhythmia in AC patients.
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