Key result
The metabolic syndrome, characterized by insulin resistance, hypertension, and inflammation, is hypothesized to be associated with accelerated aging and nonatherosclerotic chronic conditions.
Why the study?
Is the metabolic syndrome associated with accelerated aging and nonatherosclerotic chronic conditions?
Is the metabolic syndrome associated with accelerated aging and nonatherosclerotic chronic conditions?
This review proposes the hypothesis that metabolic syndrome contributes to accelerated aging and various nonatherosclerotic chronic conditions.
Answers are grounded in this paper and cite their sources.
Metabolic syndrome may accelerate aging beyond atherosclerosis; leaves open causal validation in prospective studies.
In this article we review the association of three principal factors of the metabolic syndrome-- insulin resistance, hypertension, and increased levels of inflammation factors--with several chronic, nonatherosclerotic conditions associated with aging--frailty, cognitive decline, impaired cardiovascular autonomic control, and possibly osteoporosis. We hypothesize that the metabolic syndrome is associated with "accelerated" aging.
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Barzilay et al. (2011) conducted a review in Metabolic syndrome and age-related, nonatherosclerotic, chronic medical conditions. Metabolic syndrome was evaluated. The metabolic syndrome, characterized by insulin resistance, hypertension, and inflammation, is hypothesized to be associated with accelerated aging and nonatherosclerotic chronic conditions.
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