What question did this study set out to answer?

To investigate the local and regional variations in myofibrillar patterns during heart looping in embryonic rat hearts.

May 1, 1996The Anatomical RecordOpen Access

Local and regional variations in myofibrillar patterns in looping rat hearts

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Population

Embryonic day (ED) 9.5 to 11.5 rat hearts

Design

Preclinical

Authors

RPRobert L. PriceHeart Failure / Cardiomyopathy CCC. ChintanowongesUniversity of South Carolina ISIsao ShiraishiOsaka City University

Discussion

Member takes

Implication

Supports cytodifferentiation in looping; extends avian data but remains hypothesis-generating for mammals.

Key Points

To investigate the local and regional variations in myofibrillar patterns during heart looping in embryonic rat hearts.
Utilized transmission electron microscopy (TEM) and confocal scanning laser microscopy (CSLM) on embryonic rat hearts aged 9.5 to 11.5 days.
Employed 3-D reconstruction techniques to analyze myofibrillar patterns.
Myofibrils near the lumen exhibited primarily circumferential arrangements, while those near the pericardial surface were mostly longitudinal at 9.5 days.
Regional variations in myofibrillar organization were evident in cardiac cushions and trabeculae in older embryos.

Structured PICO

Population

Embryonic day (ED) 9.5 to 11.5 rat hearts

Intervention

Transmission electron microscopy (TEM), confocal scanning laser microscopy (CSLM), and 3-D reconstruction techniques

Outcome

Local and regional variations and right side dominance in myofibrillar patterns during heart loopingsurrogate

The local and regional patterns of myofibrils in looping rat hearts are similar to developing chicken hearts, indicating cytodifferentiation and contractile apparatus development play a crucial role in heart looping.

Cite This Study

Price et al. (1996) studied this question.

synapsesocial.com/papers/6a2124a13fc57ec05c1e4bd3 https://doi.org/10.1002/(sici)1097-0185(199605)245:1<83::aid-ar13>3.0.co;2-5

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Local and regional variations in myofibrillar patterns in looping rat hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Local and regional variations in myofibrillar patterns in looping rat hearts

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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