Key result
In early chick embryonic hearts, the first myofibrils are already bound to cell membranes through adherens junctions or costameres, suggesting cell membranes direct nascent myofibril organization.
The study demonstrates that early cardiac myofibrils are firmly bound to myocyte cell membranes, suggesting the membrane plays an essential role in directing the spatial organization of nascent myofibrils.
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Does not support clinical changes in congenital heart disease; leaves open membrane guidance in mammalian cardiogenesis.
K. T. Tokuyasu (1989) studied Cardiac myofibrillogenesis. Immunocytochemical labeling was evaluated on Generation of fasciae adherentes and costameres and myofibril organization. In early chick embryonic hearts, the first myofibrils are already bound to cell membranes through adherens junctions or costameres, suggesting cell membranes direct nascent myofibril organization.