What question did this study set out to answer?

To investigate the association between neuropeptide Y levels and ischemic response to exercise in coronary artery disease patients.

August 29, 2000CirculationOpen Access

Postexercise Ischemia Is Associated With Increased Neuropeptide Y in Patients With Coronary Artery Disease

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Why the study?

Is postexercise ischemia associated with increased Neuropeptide Y levels in male patients with coronary artery disease?

Population

29 male patients with effort-induced angina pectoris and coronary artery disease

Design

Cross-sectional

Authors

LGLars GullestadHeart Failure & Transplant BJBjørn JørgensenOslo University Hospital TBT BjuröWallenberg Wood Science Center

Discussion

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Implication

NPY may link to postexercise ischemia in CAD; hypothesis-generating and leaves open causality or therapeutic relevance.

Key Points

To investigate the association between neuropeptide Y levels and ischemic response to exercise in coronary artery disease patients.
Twenty-nine male patients with coronary artery disease underwent symptom-limited exercise tests.
Blood samples were collected before, during, and after exercise for neurohormonal analysis.
Ischemia was assessed using ST-segment changes and heart rate-adjusted measures.
Mean ST-segment depression was -223±20.2 microV (P:<0.0001) during exercise and -49±8.9 microV after 10 minutes (P:<0.0001).
Maximal NPY increase significantly correlated with ST-segment depression at 3 minutes post-exercise (r=-0.61, P=0.0005).
NPY levels peaked 4 minutes post-exercise, indicating a specific timing in relation to ischemia.

Structured PICO

Is postexercise ischemia associated with increased Neuropeptide Y levels in male patients with coronary artery disease?

Population

29 male patients with effort-induced angina pectoris and coronary artery disease

Intervention

Symptom-limited exercise test

Outcome

Correlation between plasma Neuropeptide Y (NPY) levels and the degree and duration of ST-segment depression after exercisesurrogate

Plasma Neuropeptide Y levels correlate with the degree and duration of postexercise ST-segment depression, suggesting NPY may contribute to myocardial ischemia in patients with coronary artery disease.

Cite This Study

Gullestad et al. (2000) studied this question.

synapsesocial.com/papers/6a2124bcf9ede0d10bc3b32f https://doi.org/10.1161/01.cir.102.9.987

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Postexercise Ischemia Is Associated With Increased Neuropeptide Y in Patients With Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Postexercise Ischemia Is Associated With Increased Neuropeptide Y in Patients With Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider