Key result
CHF is linked to ~4x higher resting venous NPY levels that correlate with heart rate recovery.
Why the study?
Whether circulating neuropeptide Y levels increase during exercise in congestive heart failure when already elevated is controversial.
Do circulating neuropeptide Y (NPY) levels increase during exercise in CHF patients and correlate with performance indices?
Population
15 CHF patients on contemporary therapy and 16 age- and sex-matched controls with normal left ventricular function
Comparison
CHF patients vs age- and sex-matched controls during cardiopulmonary exercise testing
Design
Case-control study
Authors
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Does not support NPY measurement in CHF care; hypothesis-generating for autonomic assessment during exercise.
Case-Control (n=31)
Do circulating neuropeptide Y (NPY) levels increase during exercise in CHF patients and correlate with performance indices?
Absolute Event Rate: 40% vs 9%
p-value: p=<0.0001
Circulating NPY levels increase during exercise in CHF patients and correlate with heart rate recovery, suggesting NPY dynamics may provide insights into sympathetic responses and prognosis.
Ayagama et al. (2025) conducted a case-control in Congestive heart failure (n=31). Cardiopulmonary exercise testing vs. Age- and sex-matched patients with normal left ventricular function was evaluated on Resting venous NPY levels (p=<0.0001). In CHF patients, resting venous NPY levels were significantly higher than in controls (40 vs 9.0 pg/mL; P<0.0001) and increased significantly during exercise, correlating with heart rate recovery.
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