Why the study?
Does venous neuropeptide Y receptor responsiveness differ in patients with chronic heart failure compared to healthy controls?
Population
46 subjects, comprising 14 patients with chronic heart failure and LVEF <20%, 16 patients with chronic heart…
Comparison
Infusion of increasing doses of neuropeptide Y… vs Healthy control subjects and comparison between…
Design
Cross-sectional
Authors
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May contribute to venoconstriction in moderate systolic HF; hypothesis-generating and requires prospective validation.
Does venous neuropeptide Y receptor responsiveness differ in patients with chronic heart failure compared to healthy controls?
In vivo venous neuropeptide Y receptor responsiveness is increased in patients with chronic heart failure and LVEF 20-35%, which may contribute to venoconstriction at this stage of the disease.
Feng et al. (2000) studied this question.
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