Relation of the heart remodeling and endothelial dysfunction in chronic heart failure patients

Aim. To study relation of the heart remodeling processes and endothelial dysfunction in patients with chronic heart failure (CHF). Material and methods. Totally, 103 patients studied with post infarction cardiosclerosis. All patients selected to 3 groups by functional class (FC): I group consisted of 28 patients with CHF I FC, II — 46 patients with II FC and III — 29 patients with III FC by NYHA. All patients underwent echocardiography, dopplerography of brachial artery. Results. Post infarction remodeling of the left ventricle (LV) led not only to structural remodeling of LV, with chamber dilation, walls thinning, contractility decrease, but to changes of LV geometry. Contractility decrease of LV myocardium followed by the disordered endothelium-dependent vessel dilation, with increase of pulsative and resistive indexes, sensitivity decrease of brachial artery to the shift tension. Conclusion. In CHF patients the processes of heart remodeling followed by remodeling of vessels, showing functional and humoral parameters of endothelial dysfunction.