What question did this study set out to answer?

This study aims to investigate whether CD95-dependent apoptosis is responsible for T-lymphocyte downregulation after acute viral infection.

November 1, 1996Journal of VirologyOpen Access

T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions

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Randomized trial explores immune downregulation in mice post-viral infection, suggesting alternative mechanisms.

This study aims to investigate whether CD95-dependent apoptosis is responsible for T-lymphocyte downregulation after acute viral infection.
Infection of CD95- and CD95L-deficient mice with lymphocytic choriomeningitis virus (LCMV).
Comparison of T-cell expansion and cytolytic function in lymphocytes from normal and deficient mice.
Assessment of apoptotic cell numbers in mouse spleens during recovery from infection.
LCMV-infected lpr and gld mice showed normal T-cell expansion and cytolytic function.
Despite normal cytolytic activity, these mice had significant apoptotic cells in their spleens post-infection.
T-cell numbers and activity decreased to normal levels after recovery, indicating CD95 is not necessary for downregulation.

Lohman et al. (1996) studied this question.

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