Why the study?
Do long-acting natriuretic peptide, vessel dilator, kaliuretic peptide, and atrial natriuretic peptide decrease human prostate adenocarcinoma cell number and DNA synthesis?
Population
Human prostate adenocarcinoma cells
Comparison
Four peptide hormones at concentrations from 1… vs Respective antibodies to block the effect
Design
Preclinical
Follow-up
24 hours to 3 days
Authors
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Hypothesis-generating for prostate cancer; leaves open any clinical translation from in vitro data.
Do long-acting natriuretic peptide, vessel dilator, kaliuretic peptide, and atrial natriuretic peptide decrease human prostate adenocarcinoma cell number and DNA synthesis?
Four natriuretic peptide hormones specifically and potently decrease human prostate cancer cell numbers by up to 97% within 24 hours in vitro.
Vesely et al. (2005) studied this question.
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