Why the study?
Does injection directly into the sinus node artery produce sinus bradycardia in dogs?
Does injection directly into the sinus node artery produce sinus bradycardia in dogs?
Direct injection into the sinus node artery produces sinus bradycardia in dogs, likely due to mechanical distension of the artery, suggesting a potential mechanism for autoregulation of normal heart rate.
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Caution against human extrapolation from this canine model; leaves open mechanical sinus node autoregulation for further investigation.
James et al. (1963) studied this question.
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