Why the study?
Do remifentanil, sufentanil, fentanyl, and alfentanil alter inotropic and lusitropic variables in isolated human right atrial trabeculae?
Population
Isolated human right atrial trabeculae obtained from patients scheduled for coronary bypass surgery or…
Comparison
Cumulative concentrations of remifentanil… vs Control group
Design
Preclinical
Authors
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Alfentanil may depress contractility in isolated human atrial tissue; leaves open clinical relevance in vivo.
Do remifentanil, sufentanil, fentanyl, and alfentanil alter inotropic and lusitropic variables in isolated human right atrial trabeculae?
Alfentanil, unlike remifentanil, sufentanil, and fentanyl, induces a dose-dependent negative inotropic effect in isolated human right atrial tissue, which can be reversed by increasing extracellular calcium.
Hanouz et al. (2001) studied this question.
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