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October 1, 1984Acta Anaesthesiologica Scandinavica

Haemodynamic Effects of Fentanyl or Alfentanil as Adjuvants to Etomidate for Induction of Anaesthesia in Cardiac Patients

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Why the study?

Does alfentanil compared to fentanyl as an adjuvant to etomidate improve haemodynamic stability during induction of anaesthesia in patients undergoing cardiac surgery?

Population

Patients undergoing cardiac surgery

Comparison

Alfentanil 5 mg administered in combination with… vs Fentanyl 0.5 mg administered in combination with…

Design

Other

Authors

CSC. K. SpissUniversity Clinic of TraumatologyFCF. CoraimUniversity of ViennaWHW. HaiderUniversity of Vienna

Discussion

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Implication

Alfentanil was associated with greater MAP reduction than fentanyl; low-level evidence leaves optimal opioid choice open for etomidate induction.

Structured PICO

Does alfentanil compared to fentanyl as an adjuvant to etomidate improve haemodynamic stability during induction of anaesthesia in patients undergoing cardiac surgery?

P
Population
Patients undergoing cardiac surgery
I
Intervention
Alfentanil 5 mg administered in combination with etomidate for induction of anaesthesia
C
Comparator
Fentanyl 0.5 mg administered in combination with etomidate for induction of anaesthesia
O
Outcome
Haemodynamic effects (heart rate, cardiac index, mean pulmonary artery pressure, mean arterial pressure, and systemic vascular resistance)surrogate

Alfentanil is associated with a greater degree of cardiovascular depression, including a significantly greater decrease in mean arterial pressure, compared to fentanyl when used with etomidate for anaesthesia induction in cardiac surgery.

Cite This Study

Spiss et al. (1984) studied this question.

synapsesocial.com/papers/6a84252a7b4d6f59a47bf6edhttps://doi.org/10.1111/j.1399-6576.1984.tb02118.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anesthetic Requirements and Cardiovascular Effects of Fentanyl-Oxygen and Fentanyl-Diazepam-Oxygen Anesthesia in Man1978 · 295 citations
  2. 2The Pharmacokinetics of Alfentanil (R39209): A New Opioid Analgesic1982 · 152 citations
  3. 3Cardiovascular and Pulmonary Responses following Etomidate Induction of Anesthesia in Patients with Demonstrated Cardiac Disease1979 · 167 citations