Key result
Alfentanil blunts hemodynamic changes but not sympathetic responses to rapid desflurane increases.
Why the study?
Fentanyl partially blunts the hemodynamic effects of desflurane but fails to attenuate the sympathetic response, prompting evaluation of alfentanil's effects.
Does alfentanil reduce the neurocirculatory responses to desflurane in healthy male volunteers?
Comparison
Alfentanil 10 or 20 microgram/kg IV bolus vs placebo IV bolus with propofol and desflurane
Design
Randomized controlled trial
Follow-up
11 minutes
Authors
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Alfentanil permits hemodynamic stabilization during desflurane induction; extends evidence of dissociated sympathetic and circulatory responses.
RCT (n=25)
randomized
Does alfentanil reduce the neurocirculatory responses to desflurane in healthy male volunteers?
Alfentanil effectively blunts the hemodynamic changes (tachycardia and hypertension) but not the sympathetic nervous system activation associated with rapid increases in inspired desflurane.
Yonker-Sell et al. (1996) conducted an RCT in Healthy volunteers undergoing anesthesia (n=25). Alfentanil vs. Placebo was evaluated on Neurocirculatory responses (mean arterial pressure, heart rate, and sympathetic nerve activity). Alfentanil effectively blunted the hemodynamic changes (heart rate and mean arterial pressure) but not the sympathetic responses associated with rapid increases in inspired desflurane.
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