Key result
Etomidate/fentanyl limits maximal MAP decrease to ~12% vs thiopental/fentanyl in poor LV function.
Why the study?
Does etomidate/fentanyl compared to thiopental/fentanyl improve haemodynamic stability during anaesthetic induction in patients with coronary artery disease and poor left ventricular function undergoing CABG?
Population
20 patients with coronary artery disease and poor left ventricular function scheduled for elective coronary…
Comparison
Etomidate and fentanyl for anaesthetic induction vs Thiopental and fentanyl for anaesthetic induction
Design
RCT, Patients were allocated randomly
Follow-up
5 minutes after intubation
Authors
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Favors etomidate/fentanyl for induction in CABG patients with poor LV function; confirms hemodynamic advantage over thiopental/fentanyl.
RCT (n=20)
randomized
No
Does etomidate/fentanyl compared to thiopental/fentanyl improve haemodynamic stability during anaesthetic induction in patients with coronary artery disease and poor left ventricular function undergoing CABG?
Absolute Event Rate: 12% vs 32%
p-value: p=<0.05
Etomidate/fentanyl induction results in less reduction of blood pressure compared to thiopental/fentanyl in CABG patients with poor left ventricular function.
Rahman et al. (2013) conducted an RCT in Coronary artery disease with poor left ventricular function (n=20). Etomidate / fentanyl vs. Thiopental / fentanyl was evaluated on Maximal decrease in mean arterial pressure (p=<0.05). Etomidate/fentanyl induction resulted in a smaller maximal decrease in mean arterial pressure compared to thiopental/fentanyl (12% vs 32%; P<0.05) in patients with poor left ventricular function.
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