Key result
Propofol induction resulted in a significantly lower systemic vascular resistance index compared to etomidate in patients undergoing coronary artery bypass surgery.
Why the study?
Does propofol compared to etomidate improve haemodynamic stability during induction of general anaesthesia in patients undergoing elective coronary artery bypass surgery?
Population
40 adult patients aged 35-65 years, ASA grades 1 and 2, undergoing elective coronary artery bypass surgery…
Comparison
Intravenous propofol injection titrated to a… vs Intravenous etomidate injection titrated to a…
Design
RCT, divided randomly into two groups of 20 patients each
Follow-up
during induction and intubation
Authors
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Propofol warrants hemodynamic caution during CABG induction; confirms etomidate's relative afterload stability versus propofol in this RCT.
RCT (n=40)
Double-blind
Computer aided
No
Does propofol compared to etomidate improve haemodynamic stability during induction of general anaesthesia in patients undergoing elective coronary artery bypass surgery?
Absolute Event Rate: 2201.3% vs 2630.82%
p-value: p=0.022
Propofol produces a larger reduction in contractility and afterload compared to etomidate during induction for CABG, but etomidate is less effective at preventing the stress response to intubation.
Shivanna et al. (2015) conducted an RCT in Coronary artery disease requiring CABG (n=40). Propofol vs. Etomidate was evaluated on Systemic vascular resistance index (SVRI) after induction (p=0.022). Propofol induction resulted in a significantly lower systemic vascular resistance index compared to etomidate in patients undergoing coronary artery bypass surgery.
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