Key result
Etomidate provided superior hemodynamic stability compared to propofol during induction for CABG, maintaining significantly higher mean arterial pressure at 3 minutes post-intubation (100.85 vs 96.64 mmHg, p<0.001).
Why the study?
Maintaining hemodynamic stability during induction and obtunding the intubation stress response are primary considerations in general anesthesia, warranting a comparison between etomidate and propofol in CABG surgery.
Does etomidate improve hemodynamic stability compared to propofol during induction of anaesthesia in patients undergoing CABG?
Population
Eighty patients undergoing CABG surgery
Comparison
Etomidate vs propofol for induction of anesthesia
Design
Prospective, double-blind randomized clinical trial
Follow-up
5 min after induction
Authors
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Supports etomidate over propofol for CABG induction to preserve MAP; confirms hemodynamic advantage in cardiac anesthesia RCTs.
RCT (n=80)
Double-blind
Computer generated random number list
No
Does etomidate improve hemodynamic stability compared to propofol during induction of anaesthesia in patients undergoing CABG?
Absolute Event Rate: 100.85% vs 96.64%
p-value: p=<0.001
Etomidate provides better hemodynamic stability than propofol during induction of anesthesia for CABG surgery.
Hossain et al. (2021) conducted an RCT in Coronary Artery Bypass Graft Surgery (CABG) (n=80). Etomidate vs. Propofol (1.5-2 mg/kg IV) was evaluated on Mean Arterial Pressure (MAP) at 3 minutes after intubation (p=<0.001). Etomidate provided superior hemodynamic stability compared to propofol during induction for CABG, maintaining significantly higher mean arterial pressure at 3 minutes post-intubation (100.85 vs 96.64 mmHg, p<0.001).
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