Key result
High-dose oral clonidine (4-4.5 mcg/kg) provided significantly better postoperative analgesia than low-dose clonidine (2-2.5 mcg/kg) but caused more hypotension and bradycardia.
Why the study?
To evaluate the effectiveness of oral clonidine as preanesthetic medication and determine which dose provides safe and better postoperative analgesia in patients undergoing gynaecological laparotomy.
Does high dose oral clonidine compared to low dose oral clonidine improve post-operative analgesia in adult females undergoing gynaecological laparotomy?
Comparison
Low dose clonidine 2-2.5 mcg/kg vs high dose clonidine 4-4.5 mcg/kg
Design
Prospective, randomized, double-blind, controlled study
Follow-up
6 hours in postoperative period
Authors
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High-dose clonidine may enhance postoperative analgesia but risks more hypotension and bradycardia; leaves open optimal dosing for clinical use.
RCT (n=60)
Double-blind
Randomized
No
Does high dose oral clonidine compared to low dose oral clonidine improve post-operative analgesia in adult females undergoing gynaecological laparotomy?
Absolute Event Rate: 3.3% vs 4.95%
p-value: p=0.001
Low dose oral clonidine (2-2.5 mcg/kg) provides safe and effective postoperative analgesia with stable hemodynamics, whereas higher doses (4-4.5 mcg/kg) improve analgesia but increase the risk of marked hypotension and bradycardia.
Mahbub et al. (2022) conducted an RCT in Abdominal gynaecological surgery (n=60). Oral clonidine vs. Low dose oral clonidine (2-2.5 mcg/kg) was evaluated on Visual Analog Scale (VAS) score for pain at 1 hour postoperatively (p=0.001). High-dose oral clonidine (4-4.5 mcg/kg) provided significantly better postoperative analgesia than low-dose clonidine (2-2.5 mcg/kg) but caused more hypotension and bradycardia.
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