Key result
Perioperative clonidine prevents intense anxiety and maintains intraoperative HR <70 bpm in ~68% of patients vs placebo.
Why the study?
The clinical effect of small oral clonidine doses on anxiolysis, analgesia, and hemodynamic stability in patients undergoing abdominal hysterectomy was assessed to explore its potential as a preoperative sedative alternative.
Does oral clonidine improve anxiolysis, analgesia, and hemodynamic stability in patients undergoing abdominal hysterectomy?
Population
61 patients, ASA status I–II, undergoing abdominal hysterectomy
Comparison
Oral clonidine 100 μg vs placebo before surgery and 24 h after surgery
Design
Double-blind randomized placebo-controlled trial
Follow-up
72 h after surgery
Authors
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Supports low-dose oral clonidine for anxiolysis and hemodynamic stability in hysterectomy; extends RCT evidence for perioperative alpha-2 agonism.
RCT (n=61)
Double-blind
randomly assigned
Does oral clonidine improve anxiolysis, analgesia, and hemodynamic stability in patients undergoing abdominal hysterectomy?
Number Needed to Treat: 2 (95% CI 1.29–2.8)
Absolute Event Rate: 68% vs 21.4%
Number Needed to Treat: 2
Oral clonidine 100 μg given perioperatively provides clinically relevant anxiolysis and analgesia in patients undergoing abdominal hysterectomy.
Hidalgo et al. (2005) conducted an RCT in Abdominal hysterectomy (n=61). Oral clonidine vs. Placebo was evaluated on Average heart rate less than 70 bpm during surgery (NNT 2, 95% CI 1.29-2.80). Oral clonidine 100 μg given perioperatively prevented intense anxiety in patients with moderate to intense pain (NNT 3) and maintained intraoperative heart rate <70 bpm in 68% vs 21.4% on placebo.
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