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July 25, 2016Health RenaissanceOpen Access

The propofol induction dose was significantly lower in the clonidine 150 mcg (1.2±0.2 mg/kg) and 300 mcg (1.08±0.24 mg/kg) groups compared to placebo (1.4±0.3 mg/kg) (p<0.001).

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Why the study?

Does oral clonidine premedication reduce propofol consumption in patients undergoing laparoscopic cholecystectomy?

Population

90 consecutive patients undergoing laparoscopic cholecystectomy

Comparison

Oral clonidine 150 mcg or 300 mcg given 60… vs Placebo given 60 minutes before induction of…

Design

RCT, randomly divided into three equal groups, double-blind

Authors

JPJagat Narayan PrasadSSS. N. SinghKPKashmira Pokhrel

Discussion

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Overview

Oral clonidine may lower propofol needs in laparoscopic cholecystectomy; leaves open confirmation before practice change.

Structured PICO

Does oral clonidine premedication reduce propofol consumption in patients undergoing laparoscopic cholecystectomy?

P
Population
90 consecutive patients undergoing laparoscopic cholecystectomy
I
Intervention
Oral clonidine 150 mcg or 300 mcg given 60 minutes before induction of anaesthesia
C
Comparator
Placebo given 60 minutes before induction of anaesthesia
O
Outcome
Propofol consumption (induction dose for loss of verbal command and maintenance infusion rate)surrogate

Oral clonidine premedication significantly reduces the propofol requirement for induction and maintenance of anesthesia during laparoscopic cholecystectomy.

Cite This Study

Prasad et al. (2016) studied this question.

synapsesocial.com/papers/6a701f76fe4101aa97e00608https://doi.org/10.3126/hren.v12i3.15322
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