Key result
Preanesthetic medication with 5.0 microg/kg oral clonidine significantly prolonged the time required to respond to verbal commands compared to control (14.9 vs 8.2 minutes; P<0.01).
Why the study?
Does oral clonidine premedication delay arousal and reduce awakening concentration of propofol in healthy male patients undergoing orthopedic surgery?
RCT (n=72)
Does oral clonidine premedication delay arousal and reduce awakening concentration of propofol in healthy male patients undergoing orthopedic surgery?
Absolute Event Rate: 14.9% vs 8.2%
p-value: p=< 0.01
Preanesthetic medication with 5 microg/kg oral clonidine delays recovery from propofol/fentanyl anesthesia and decreases the awakening propofol concentration.
No takes yet. Share an insight, caveat, or question.
May delay emergence from propofol anesthesia; leaves open effects on ambulatory recovery times.
Higuchi et al. (2002) conducted an RCT in Healthy patients undergoing elective orthopedic surgery (n=72). Oral clonidine vs. Control (no premedication) was evaluated on Time required to respond to a verbal command (p=< 0.01). Preanesthetic medication with 5.0 microg/kg oral clonidine significantly prolonged the time required to respond to verbal commands compared to control (14.9 vs 8.2 minutes; P<0.01).
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