Why the study?
Does oral clonidine premedication reduce sevoflurane requirements and anesthetic induction time in adults undergoing general anesthesia?
Population
104 adult patients aged 30-48 yr scheduled to undergo general anesthesia.
Comparison
Oral clonidine 4.5 µg/kg administered 1.5 h… vs Control group receiving no clonidine…
Design
Other
Authors
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May shorten sevoflurane induction; hypothesis-generating for MAC reduction and requires randomized confirmation before practice change.
Does oral clonidine premedication reduce sevoflurane requirements and anesthetic induction time in adults undergoing general anesthesia?
Oral clonidine premedication significantly reduces the time required for anesthetic induction and the minimum alveolar concentration of sevoflurane needed to prevent response to verbal command.
Inomata et al. (1999) studied this question.
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