Why the study?
Does oral clonidine premedication reduce the awakening concentration of sevoflurane in children?
Population
63 ASA physical status I children (age range 2-10 yr)
Comparison
Clonidine 2 μg/kg or 4 μg/kg orally, 100 min… vs Placebo orally, 100 min before induction of…
Design
RCT, Randomly divided into three groups
Follow-up
Immediate post-operative period
Authors
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Supports 2 μg/kg clonidine premedication to lower sevoflurane emergence thresholds in children; extends adult data with RCT confirmation and no added benefit at 4 μg/kg.
Does oral clonidine premedication reduce the awakening concentration of sevoflurane in children?
Oral clonidine premedication at 2 μg/kg significantly reduces the awakening concentration of sevoflurane in children, with no additional benefit at 4 μg/kg.
Kihara et al. (2000) studied this question.
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