Why the study?
Does oral clonidine premedication reduce sevoflurane requirements for anaesthesia and hypnosis in surgical patients?
Population
42 patients scheduled for surgery (n=21 per group)
Comparison
Clonidine 5 micrograms.kg-1 orally 90 min before… vs No premedication
Design
RCT, random allocation
Authors
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Oral clonidine premedication lowers sevoflurane MAC; confirms its role as an anesthetic-sparing adjunct.
Does oral clonidine premedication reduce sevoflurane requirements for anaesthesia and hypnosis in surgical patients?
Oral clonidine premedication significantly reduces sevoflurane requirements for both anesthesia and hypnosis.
Katoh et al. (1997) studied this question.
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