Key result
Etomidate provided more stable hemodynamics during general anesthesia induction compared to propofol, with significantly higher mean arterial pressure after induction (94.33 vs 85.53 mmHg, p=0.020).
Why the study?
The study was designed to compare the degree of attenuation of hemodynamic response to induction, laryngoscopy, and endotracheal intubation between etomidate and propofol in noncardiac surgery.
Does etomidate improve hemodynamic stability compared to propofol during induction and endotracheal intubation in patients undergoing non-cardiac surgery?
RCT (n=60)
Double-blind
Randomly selected
No
Does etomidate improve hemodynamic stability compared to propofol during induction and endotracheal intubation in patients undergoing non-cardiac surgery?
Absolute Event Rate: 94.33% vs 85.53%
p-value: p=0.020
Etomidate provides superior hemodynamic stability compared to propofol during the induction of general anesthesia in patients undergoing non-cardiac surgeries.
Etomidate may better preserve post-intubation hemodynamics than propofol; leaves open optimal agent selection pending higher-level trials.
Background: This study is designed to compare the degree of attenuation of hemodynamic response to induction, laryngoscopy and endotracheal intubation of etomidate with those of propofol in patients undergoing noncardiac surgical procedures. Methods: The present study conducted in Non Cardiac Surgeries in the Department of Anaesthesiology, Jhalawar Medical College & Associated Hospitals, Jhalawar, Rajasthan.After institutional ethical committee’s approval and written informed consent from the patient’s attendant in the format as per proforma, the present study was conducted on 60 patients of ASA Grade I and II of either sex, aged 18 to 60 years, scheduled for a variety of non-cardiac surgical procedures requiring general anaesthesia. Results: The findings of the study suggest that use of etomidate as inducing agent provides more hemodynamic stability as compared to propofol and can be preffered in patients prone to hemodynamic instability, cardiovascular abnormalities, hypovolemia, prone to renal failure due to hypotension. Propofol may be preffered for induction where hypertension is contraindicated or hypotension is preffered and myoclonus is to be avoided. Conclusion: Etomidate provides a more stable hemodynamics during general anesthesia as compared to propofol.
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Rathore et al. (2020) conducted an RCT in Non-cardiac surgical procedures requiring general anaesthesia (n=60). Etomidate vs. Propofol 2 mg/kg was evaluated on Mean arterial pressure after induction (p=0.020). Etomidate provided more stable hemodynamics during general anesthesia induction compared to propofol, with significantly higher mean arterial pressure after induction (94.33 vs 85.53 mmHg, p=0.020).
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