Key result
A combination of etomidate and propofol significantly attenuated the increase in heart rate (74.4 vs 84.8 bpm, p=0.0001) and mean arterial pressure at 1 minute post-induction compared to etomidate alone.
Why the study?
Haemodynamic changes during laryngoscopy and intubation are a major concern during induction under general anaesthesia.
Does a combination of etomidate and propofol improve haemodynamic stability compared to etomidate alone in patients undergoing elective surgery under general anaesthesia?
RCT (n=60)
Single-blind
Randomized
No
Does a combination of etomidate and propofol improve haemodynamic stability compared to etomidate alone in patients undergoing elective surgery under general anaesthesia?
Absolute Event Rate: 74.4% vs 84.8%
p-value: p=0.0001
A combination of etomidate and propofol provides better haemodynamic stability during induction and intubation compared to etomidate alone in patients undergoing elective surgery.
Supports etomidate-propofol for hemodynamic stability at induction; confirms superiority over etomidate alone in elective surgery.
Haemodynamic changes during laryngoscopy and intubation are the major concern during induction under general anaesthesia. Our study aims to compare the haemodynamic changes between etomidate versus a combination of etomidate and propofol.
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Puri et al. (2019) conducted an RCT in Elective surgery under general anaesthesia (n=60). Combination of etomidate and propofol (etofol) vs. Etomidate alone (0.3 mg/kg) was evaluated on Heart rate at 1 minute after induction (p=0.0001). A combination of etomidate and propofol significantly attenuated the increase in heart rate (74.4 vs 84.8 bpm, p=0.0001) and mean arterial pressure at 1 minute post-induction compared to etomidate alone.
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