What question did this study set out to answer?

This study aims to examine how blood pressure hemodynamics relate to outcomes after acute ischemic stroke.

January 17, 2012International Journal of Emergency MedicineOpen Access

The impact of blood pressure hemodynamics in acute ischemic stroke: a prospective cohort study

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Why the study?

Does a larger 24-hour blood pressure differential worsen stroke severity, functional disability, and 90-day mortality in patients with acute ischemic stroke?

Population

189 adult patients presenting to an academic emergency department with acute ischemic stroke of less than 24…

Design

Cohort

Follow-up

90 days

Authors

LGLatha GantiBrown University SES. EnduriUniversity of Colorado Anschutz Medical Campus FBFernanda BellolioMayo Clinic

Discussion

Member takes

Implication

BP variability in first 24 h may flag higher mortality risk in acute ischemic stroke; hypothesis-generating and requires prospective confirmation before practice change.

Key Points

This study aims to examine how blood pressure hemodynamics relate to outcomes after acute ischemic stroke.
Included 189 patients presenting to the emergency department with ischemic stroke within 24 hours.
Blood pressure measurements taken non-invasively at 5-minute intervals during the emergency department stay.
Used statistical tests like Spearman correlations, Wilcoxon test, and Cox models to analyze outcomes.
Larger differentials in diastolic BP (p = 0.003) and systolic BP (p < 0.001) correlated with more severe strokes.
Greater differentials in dBP (p = 0.019) and sBP (p = 0.036) linked to worse functional outcomes at discharge.
Patients with large BP differentials were more likely to die at 90 days (dBP p = 0.008, sBP p = 0.007).

Structured PICO

Does a larger 24-hour blood pressure differential worsen stroke severity, functional disability, and 90-day mortality in patients with acute ischemic stroke?

Population

189 adult patients presenting to an academic emergency department with acute ischemic stroke (AIS) of less than 24 hours onset, mean age 74.0, 58.7% male.

Intervention

Observation of 24-hour blood pressure differential (maximum minus minimum systolic and diastolic blood pressure) measured non-invasively at 5-minute intervals.

Outcome

Stroke severity (measured by NIHSS on arrival), disability at hospital discharge (modified Rankin score ≥3), and death at 90 days.hard clinical

Limitations

Hypothesis-generating study requiring confirmation in a controlled trial

Cite This Study

Ganti et al. (2012) studied this question.

synapsesocial.com/papers/6a213aa3ffa0738687c3d9de https://doi.org/10.1186/1865-1380-5-3

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Implication

BP variability in first 24 h may flag higher mortality risk in acute ischemic stroke; hypothesis-generating and requires prospective confirmation before practice change.

The impact of blood pressure hemodynamics in acute ischemic stroke: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

The impact of blood pressure hemodynamics in acute ischemic stroke: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider