Two-Year Follow-Up after Contact Force Sensing Radiofrequency Catheter and Second-Generation Cryoballoon Ablation for Paroxysmal Atrial Fibrillation: A Comparative Single Centre Study
Key result
Second-generation cryoballoon ablation resulted in a similar 2-year success rate for freedom from atrial arrhythmias compared to contact force radiofrequency ablation (67% vs 65.5%, P=0.54).
Why the study?
Does second-generation cryoballoon ablation improve freedom from AF/AT compared to contact force radiofrequency ablation in patients with symptomatic, drug-refractory paroxysmal AF?
Population
98 patients with symptomatic, drug-refractory paroxysmal atrial fibrillation undergoing their first…
Comparison
Second-generation cryoballoon ablation vs Contact force radiofrequency catheter ablation
Design
Cohort
Follow-up
24 months
Authors
Discussion
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Implication
Comparable efficacy in observational data should not change practice; leaves open need for randomized confirmation of long-term equivalence.
Study Design
Type
Cohort (n=98)
Multicenter
No
Structured PICO
Does second-generation cryoballoon ablation improve freedom from AF/AT compared to contact force radiofrequency ablation in patients with symptomatic, drug-refractory paroxysmal AF?
P
Population
98 patients with symptomatic, drug-refractory paroxysmal atrial fibrillation undergoing their first pulmonary vein isolation ablation, followed for 24 months.
E
Exposure
Second-generation cryoballoon (CB2) ablation (n=40)
C
Comparator
Contact force radiofrequency (CF-RF) catheter ablation (n=58)
O
Outcome
Success rate, defined as freedom from AF/atrial tachycardia (AT) after a single procedure without antiarrhythmic drug at 24-month follow-upcomposite
Main Result
Absolute Event Rate: 67% vs 65.5%
p-value: p=0.54
Second-generation cryoballoon and contact force radiofrequency ablation have comparable 2-year success rates and safety profiles for the treatment of paroxysmal AF.
Limitations
- Single center
- Retrospective
- Nonrandomized
Cite This Study
Kardos et al. (2016) conducted a cohort in Paroxysmal atrial fibrillation (n=98). Second-generation cryoballoon (CB2) ablation vs. Contact force radiofrequency (CF-RF) ablation was evaluated on Freedom from AF/atrial tachycardia (AT) after a single procedure without antiarrhythmic drug (p=0.54). Second-generation cryoballoon ablation resulted in a similar 2-year success rate for freedom from atrial arrhythmias compared to contact force radiofrequency ablation (67% vs 65.5%, P=0.54).