August 1, 1989Journal of Surgical Oncology
Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas
Why the study?
What are the independent prognostic variables associated with disease-free and overall survival in patients with extremity soft tissue sarcomas?
Population
300 patients with extremity soft tissue sarcomas entered into treatment protocols at the National Cancer…
Design
Cohort
Follow-up
9.5 years
Authors
Discussion
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Member takes
Implication
May inform risk stratification in extremity sarcomas; hypothesis-generating pending prospective validation.
Structured PICO
What are the independent prognostic variables associated with disease-free and overall survival in patients with extremity soft tissue sarcomas?
P
Population
300 patients with extremity soft tissue sarcomas (STS) entered into treatment protocols at the National Cancer Institute
I
Intervention
Analysis of prognostic variables including histologic grade, tumor necrosis, tumor location, mitotic activity, and vascular invasion
O
Outcome
Disease-free and overall survivalhard clinical
Histologic grade, incorporating tumor necrosis, is the most significant predictor of metastasis and mortality in extremity soft tissue sarcomas.
Cite This Study
Lack et al. (1989) studied this question.