Key result
Autophagy and mitophagy serve as important protective mechanisms in the heart during ischemia-reperfusion injury, pathological remodeling, and heart failure.
Design
Review
Authors
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Highlights autophagy pathways as potential HF therapy targets; leaves open clinical validation in prospective trials.
Autophagy and mitophagy appear to be critical adaptive mechanisms for cardioprotection and mitigating adverse cardiac remodeling, highlighting their potential as therapeutic targets.
Gottlieb et al. (2012) conducted a review in Cardiovascular disease (ischemia-reperfusion injury, hypertrophy, heart failure). Autophagy and mitophagy was evaluated. Autophagy and mitophagy serve as important protective mechanisms in the heart during ischemia-reperfusion injury, pathological remodeling, and heart failure.
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