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This perspective aims to clarify the roles of p27Kip1 and p21Cip1 in the regulation of D cyclin-cdk4 activity.

March 1, 2004Cell CycleOpen Access

Cell Cycle Control: A Complex Issue

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This perspective aims to clarify the roles of p27Kip1 and p21Cip1 in the regulation of D cyclin-cdk4 activity.
Reviewed existing studies on p27Kip1 and p21Cip1's influence on D cyclin-cdk4 complexes.
Conducted experiments to examine the assembly and activation of D cyclin-cdk4 complexes.
p27Kip1 and p21Cip1 stabilize D cyclin-cdk4 complexes but inhibit their activity.
Conflicting data from previous studies were analyzed, leading to a proposed model for cell cycle control.

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Perspective summarizes the roles of p27Kip1 and p21Cip1 in regulating D cyclin-cdk4 activity, suggesting they stabilize but inhibit it.

Olashaw et al. (2004) studied this question.

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