p21WAF1/Cip1 belongs to the Cip/Kip family of cyclin kinase inhibitors (CKI) (p21Waf1/Cip1, p27Kip1, p57Kip1). p21Waf1/Cip1 was first described as a potent and universal inhibitor of cyclin-dependent (Cdks). Two forms of functionally active p21 has been localized and described: a nuclear and a forms. In this paper the structures of p21 has been described and as well as it functional in terms of differentiation, proliferation and apoptotic activities. The upregulation of p21 by 53-dependent and p53-independent mechanisms is also described.
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Renald Blundell (2006) studied this question.
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