Restless Legs Syndrome is Associated with DSM-IV Major Depressive Disorder and Panic Disorder in the Community

The authors examined the association between restless legs syndrome (RLS) and DSM-IV major depressive disorder and panic disorder based on Wave III and IV of the Baltimore ECA follow-up study. Of 1071 participants, 1024 completed the RLS Questionnaire and Diagnostic Interview Schedule. Adjusted odds ratio for diagnosis of major depressive disorder (4.7, 95% confidence interval 1.6, 14.5) and panic disorder (12.9 3.6, 46.0) and comorbidity of major depressive disorder and panic disorder (9.7 1.4, 69.0) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder.