Why the study?
Does AT1A receptor deletion alter blood pressure and sodium excretion responses to dietary salt variations in mice?
Population
AT1A receptor-deficient (-/-) mice and wild-type mice
Comparison
Low, normal, or high-salt diet for 3 weeks vs Wild-type mice on the same diets
Design
Preclinical
Follow-up
3 weeks
Authors
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AT1A deletion findings in mice warrant no clinical changes; leaves open human relevance for salt-sensitive hypertension.
Does AT1A receptor deletion alter blood pressure and sodium excretion responses to dietary salt variations in mice?
AT1A receptor deletion in mice results in salt-sensitive blood pressure and marked alterations in the pressure-natriuresis relationship.
Mangrum et al. (2002) studied this question.
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