Why the study?
Does peak endocardial acceleration reflect heart contractility (LV dP/dtmax) during atrial fibrillation in a sheep model?
Population
6 sheep (65 +/- 6 kg)
Comparison
Induction of atrial fibrillation and monitoring… vs Sinus rhythm (baseline before AF induction)
Design
Preclinical
Follow-up
5 +/- 1.3 minutes (duration of AF)
Authors
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Should not change device algorithms yet; leaves open human validation of PEA for contractility sensing in AF.
Does peak endocardial acceleration reflect heart contractility (LV dP/dtmax) during atrial fibrillation in a sheep model?
Peak endocardial acceleration strongly correlates with LV dP/dtmax during atrial fibrillation, indicating it reliably reflects heart contractility regardless of rhythm and holds promise for use in therapeutic implantable devices.
Bombardini et al. (2000) studied this question.
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