Key result
In a sheep model, PEA I changes correlated with positive peak LVdP/dt (r=0.83, P<0.001), while PEA II changes correlated with aortic diastolic pressure (r=0.91) and negative peak LVdP/dt (r=0.92).
Effect estimate: r = 0.83 to 0.92
p-value: p=< 0.001
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Hypothesis-generating for PEA as a hemodynamic surrogate in models; human validation required before any clinical consideration.
Gianni Plicchi (2002) studied this question. Implantable haemodynamic monitor based on PEA I and PEA II measurements vs. Millar catheter measurements was evaluated on Correlation between PEA I/II changes and LVdP/dt or ADP changes (r = 0.83 to 0.92, p=< 0.001). In a sheep model, PEA I changes correlated with positive peak LVdP/dt (r=0.83, P<0.001), while PEA II changes correlated with aortic diastolic pressure (r=0.91) and negative peak LVdP/dt (r=0.92).
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