Key result
Peak endocardial acceleration strongly correlates with LVdP/dt max in ischemic hearts before and after microembolization.
Why the study?
Previous studies showed PEA tracks LV contractility in normal hearts, but its ability to track contractility changes in ischemic hearts was unknown.
Does an endocardial acceleration sensor accurately track left ventricular contractility changes in ischemic hearts?
Does an endocardial acceleration sensor accurately track left ventricular contractility changes in ischemic hearts?
Effect estimate: r = 0.83 to 0.99
p-value: p=< 0.001
An endocardial acceleration sensor in the right ventricle effectively tracks left ventricular contractility changes in an ischemic canine model, suggesting potential for chronic monitoring of mechanical function.
Endocardial sensors merit prospective human validation for contractility monitoring; leaves open clinical translation in ischemic disease.
Previous experimental studies demonstrated that in normal hearts, Peak Endocardial Acceleration (PEA), during isovolumic contraction phase, measured with an endocardial sensor (Best, Sorin) in the right ventricle (RV), tracks changes of left ventricular (LV) contractility. Aim of the study: To assess if PEA also tracks LV contractility changes in ischemic hearts resulting from coronary microembolizations (ME). Methods: Under general anaesthesia, six adult beagle dogs (12 ± 2 kg) were instrumented for chronic monitoring of LV pressure, ECG and PEA. Latex beads mixed with fluoroscopy dye were injected into the circumflex coronary artery to cause LV ischemia. Before and after ME, incremental dobutamine infusions were performed to evaluate the contractile response to adrenergic stimulation. Results: A significant correlation between PEA and LVdP /dt max was observed before and after ME. Such a strong correlation was maintained even during adrenergic stimulation (r = 0.83 to 0.99, p < 0.001). The sensor PEA appears to be an effective means for the chronic monitoring of the mechanical function of ischemic hearts.
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Marcelli et al. (2006) studied Ischemic hearts (n=6). Peak Endocardial Acceleration (PEA) sensor vs. LVdP/dt max was evaluated on Correlation between PEA and LVdP/dt max (r = 0.83 to 0.99, p=< 0.001). Peak Endocardial Acceleration measured with an endocardial sensor strongly correlated with LVdP/dt max in ischemic hearts before and after microembolization (r = 0.83 to 0.99, p < 0.001).
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