Key result
Elevated serum troponin I levels in patients with acute ischaemic stroke were associated with increased stroke severity and poor functional outcome.
Why the study?
Serum troponins have been reported to be elevated in acute cerebrovascular disease and poor clinical outcome, prompting evaluation of serum troponin I relative to acute ischaemic stroke severity and functional outcomes.
Does elevated serum troponin I predict increased severity and poor functional outcome in patients with acute ischaemic stroke?
Cohort (n=360)
Does elevated serum troponin I predict increased severity and poor functional outcome in patients with acute ischaemic stroke?
Elevated serum troponin I in acute ischemic stroke is a prognostic marker associated with greater stroke severity and worse functional outcomes.
Supports troponin I as prognostic marker in acute ischaemic stroke but should not change practice; leaves open need for prospective validation.
Background: Serum troponins have also been reported to be elevated in patients with acute cerebrovascular disease and poor clinical outcome.Methods: We prospectively evaluated 360 patients with acute ischaemic stroke (AIS) to study the relationship between serum troponin I (TnI) levels and severity of AIS and to compare serum TnI levels in patients with favourable and unfavourable functional outcomes. Results: Their mean age was 58.8 ± 13.3 years; there were 230 (63.9%) males. Majority (n = 288; 80%) had presented with anterior circulation stroke and 58 (16.1%) had posterior circulation stroke. Majority (52.5%) had large artery atherosclerosis. The median (interquartile range) National Institutes of Health Stroke Scale (NIHSS) score was 18 (16–20). Serum TnI was positive in 87 (24.2%) and negative in 273 (75.8%). The NIHSS score at admission was higher in the positive serum TnI group. Moderate-to-severe stroke, severe stroke and cardioembolic stroke were more frequently seen in the serum TnI-positive group. Outcome was favourable in 157 (47.7%) and unfavourable outcome was seen in 172 (52.3%) patients.Conclusions: Elevated serum TnI levels were associated with increased severity of AIS and poor functional outcome.
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Vengamma et al. (2020) conducted a cohort in Acute ischaemic stroke (n=360). Elevated serum troponin I (TnI) vs. Negative serum troponin I was evaluated on Severity of AIS and functional outcome. Elevated serum troponin I levels in patients with acute ischaemic stroke were associated with increased stroke severity and poor functional outcome.
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