Key result
Elevated admission troponin I levels in acute ischemic stroke patients were significantly associated with higher in-hospital mortality (50% vs 20%, p=0.041) and worse functional outcomes at discharge.
Why the study?
Does elevated troponin I at admission predict unfavorable outcome or death in acute ischemic stroke patients?
Cohort (n=198)
No
Does elevated troponin I at admission predict unfavorable outcome or death in acute ischemic stroke patients?
Absolute Event Rate: 50% vs 20%
p-value: p=0.041
Elevated initial troponin I levels in acute ischemic stroke patients are associated with unfavorable outcomes and increased in-hospital mortality.
May refine acute stroke risk stratification; hypothesis-generating and requires prospective validation before practice change.
INTRODUCTION: Stroke is one of the leading causes of morbidity and mortality. Cardiac troponins have been found to be increased in other conditions apart from the cardiac diseases, such as stroke. The aim of the study was to assess the correlation between elevated troponin I levels and stroke outcome. METHODS: This retrospective study included 198 acute ischemic stroke patients in whom troponin I levels have been obtained at admission. Exclusion criteria were concomitant acute coronary syndrome, congestive heart failure, pulmonary embolism, renal failure, rhabdomyolysis and septic conditions. RESULTS: There was a statistically significant difference in the proportion of deaths during hospitalization (p = 0.041) and modified Rankin Scale scores (p = 0.016) between the group of patients with elevated troponin I levels and the control group. Prior ischemic strokes were more common in the group with elevated troponin I levels (p = 0.032). No other differences were observed. CONCLUSIONS: Our study showed that patients with elevated initial troponin I levels are associated with unfavorable outcome or death. Stroke may be associated with mild elevation of troponin levels, contrary to higher levels which are usually related to other conditions.
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Budinčević et al. (2016) conducted a cohort in Acute ischemic stroke (n=198). Elevated troponin I levels (≥0.5 µg/L) vs. Normal troponin I levels (<0.5 µg/L) was evaluated on In-hospital mortality (p=0.041). Elevated admission troponin I levels in acute ischemic stroke patients were significantly associated with higher in-hospital mortality (50% vs 20%, p=0.041) and worse functional outcomes at discharge.
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