Key result
Women exhibited a 35% lower orthostatic tolerance to lower body negative pressure compared to men (797 vs 1235 mmHg/min; P=0.002), reflecting less responsiveness in blood pressure regulation.
Why the study?
Does female sex affect orthostatic tolerance and responsiveness of mechanisms underlying blood pressure regulation compared to male sex?
Population
17 individuals (7 females and 10 males matched for age and fitness)
Comparison
Female sex vs Male sex
Design
Cross-sectional
Authors
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Women may have lower orthostatic tolerance; this cross-sectional observation leaves open causal mechanisms and clinical relevance.
Cross-Sectional (n=17)
Does female sex affect orthostatic tolerance and responsiveness of mechanisms underlying blood pressure regulation compared to male sex?
Effect estimate: 35% lower
Absolute Event Rate: 797% vs 1235%
p-value: p=0.002
Women exhibit lower orthostatic tolerance than men, which is associated with reduced responsiveness in mechanisms underlying blood pressure regulation under orthostatic challenge.
Víctor A. Convertino (1998) conducted a cross-sectional in Orthostatic tolerance (n=17). Female sex vs. Male sex was evaluated on Lower body negative pressure (LBNP) tolerance (35% lower, p=0.002). Women exhibited a 35% lower orthostatic tolerance to lower body negative pressure compared to men (797 vs 1235 mmHg/min; P=0.002), reflecting less responsiveness in blood pressure regulation.
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