Key result
The discovery of functional compartmentation of creatine kinase on the mitochondrion and myofibril established a molecular basis for a phosphorylcreatine-creatine shuttle for energy transport in muscle.
Population
Heart and skeletal muscle
Design
Review
Authors
Loading...
May guide metabolic models in heart failure; leaves open targeted validation and therapies.
This review outlines the historical and biochemical evidence establishing the phosphorylcreatine-creatine shuttle as the primary mechanism for energy transport in heart and skeletal muscle.
Bessman et al. (1981) conducted a review in Muscle energy transport. The discovery of functional compartmentation of creatine kinase on the mitochondrion and myofibril established a molecular basis for a phosphorylcreatine-creatine shuttle for energy transport in muscle.
Synapse has enriched one closely related paper. Consider it for comparative context: