Population
Isolated intact diaphragm muscle
Comparison
18O labeling of metabolite phosphoryls from… vs Resting vs. contracting muscle
Design
Preclinical
Authors
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Hypothesis-generating for compartmentalized muscle energetics; leaves open relevance to human cardiac bioenergetics.
Energy metabolism in intact skeletal muscle demonstrates distinct slowly and rapidly metabolizing compartments of ATP at rest, suggesting that changes in metabolite concentration during contraction are highly localized.
Zeleznikar et al. (1991) studied this question.
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