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January 1, 1990Journal of Biological ChemistryOpen Access

Evidence for compartmentalized adenylate kinase catalysis serving a high energy phosphoryl transfer function in rat skeletal muscle.

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Population

Rat diaphragm (skeletal muscle)

Comparison

Contraction and oxygen deprivation vs Non-contracting muscle / basal steady state

Design

Preclinical

Authors

RZRobert J. ZeleznikarRHRichard A. HeymanRGRichard Graeff

Discussion

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Overview

Suggests adenylate kinase aids energy transfer in stressed animal muscle; leaves open relevance to human cardiac bioenergetics.

Structured PICO

P
Population
Rat diaphragm (skeletal muscle)
I
Intervention
Contraction (at different frequencies) and oxygen deprivation
C
Comparator
Non-contracting muscle / basal steady state
O
Outcome
Rates of adenylate kinase-catalyzed phosphoryl transfersurrogate

Adenylate kinase catalysis in intact muscle provides a high energy phosphoryl transfer function, with rates increasing significantly during contraction and oxygen deprivation.

Cite This Study

Zeleznikar et al. (1990) studied this question.

synapsesocial.com/papers/6a7f4fe0d6046e930f462ec2https://doi.org/10.1016/s0021-9258(19)40230-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adenylate Kinase-catalyzed Phosphoryl Transfer Couples ATP Utilization with Its Generation by Glycolysis in Intact Muscle1995 · 113 citations
  2. 2Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle1996 · 100 citations
  3. 3Adenylate Kinase–Catalyzed Phosphotransfer in the Myocardium1999 · 209 citations
  4. 4Kinetics and compartmentation of energy metabolism in intact skeletal muscle determined from 18O labeling of metabolite phosphoryls1991 · 44 citations
  5. 5Skeletal muscle contractile performance and ADP accumulation in adenylate kinase-deficient mice2005 · 48 citations